Title |
Enriching Nanoparticles via Acoustofluidics
|
---|---|
Published in |
ACS Nano, January 2017
|
DOI | 10.1021/acsnano.6b06784 |
Pubmed ID | |
Authors |
Zhangming Mao, Peng Li, Mengxi Wu, Hunter Bachman, Nicolas Mesyngier, Xiasheng Guo, Sheng Liu, Francesco Costanzo, Tony Jun Huang |
Abstract |
Focusing and enriching submicrometer and nanometer scale objects is of great importance for many applications in biology, chemistry, engineering, and medicine. Here, we present an acoustofluidic chip that can generate single vortex acoustic streaming inside a glass capillary through using low-power acoustic waves (only 5 V is required). The single vortex acoustic streaming that is generated, in conjunction with the acoustic radiation force, is able to enrich submicrometer- and nanometer-sized particles in a small volume. Numerical simulations were used to elucidate the mechanism of the single vortex formation and were verified experimentally, demonstrating the focusing of silica and polystyrene particles ranging in diameter from 80 to 500 nm. Moreover, the acoustofluidic chip was used to conduct an immunoassay in which nanoparticles that captured fluorescently labeled biomarkers were concentrated to enhance the emitted signal. With its advantages in simplicity, functionality, and power consumption, the acoustofluidic chip we present here is promising for many point-of-care applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 155 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 32% |
Student > Master | 14 | 9% |
Researcher | 13 | 8% |
Student > Bachelor | 7 | 4% |
Student > Doctoral Student | 4 | 3% |
Other | 12 | 8% |
Unknown | 56 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 51 | 33% |
Materials Science | 11 | 7% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Chemistry | 6 | 4% |
Agricultural and Biological Sciences | 5 | 3% |
Other | 20 | 13% |
Unknown | 57 | 37% |