| Title |
Sperm-Hybrid Micromotor for Targeted Drug Delivery
|
|---|---|
| Published in |
ACS Nano, December 2017
|
| DOI | 10.1021/acsnano.7b06398 |
| Pubmed ID | |
| Authors |
Haifeng Xu, Mariana Medina-Sánchez, Veronika Magdanz, Lukas Schwarz, Franziska Hebenstreit, Oliver G. Schmidt |
| Abstract |
A sperm-driven micromotor is presented as a targeted drug delivery system, which is appealing to potentially treat diseases in the female reproductive tract. This system is demonstrated to be an efficient drug delivery vehicle by first loading a motile sperm cell with doxorubicin hydrochloride (DOX-HCl, an anticancer drug), then guiding it, using a synthetic magnetic harness, to an in vitro cultured tumor spheroid, and finally delivering the drug locally once the sperm cell is free by an integrated mechanical release mechanism. The sperm release mechanism is designed to liberate the sperm when it hits the tumor walls, allowing the sperm to swim into the tumor and deliver the drug through sperm-cancer cell membrane fusion. In our experiments, sperm cells exhibited a high drug encapsulation capability and drug carrying stability, convenient to minimize the toxic effects and unwanted drug accumulation in healthy tissues. Moreover, sperms are excellent candidates to operate in physiological environments, as they do neither express pathogenic proteins nor proliferate to form undesirable colonies, unlike other cells or microorganisms. Overall, this sperm-hybrid micromotor is a biocompatible platform that can be used in gynecological healthcare, treating or detecting cancer or other diseases in the female reproductive system in the future. |
X Demographics
The data shown below were collected from the profiles of 183 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 24 | 13% |
| United Kingdom | 8 | 4% |
| Japan | 7 | 4% |
| Canada | 6 | 3% |
| Australia | 5 | 3% |
| Spain | 4 | 2% |
| France | 3 | 2% |
| Nepal | 2 | 1% |
| India | 2 | 1% |
| Other | 20 | 11% |
| Unknown | 102 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 152 | 83% |
| Scientists | 21 | 11% |
| Practitioners (doctors, other healthcare professionals) | 7 | 4% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 334 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 334 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 66 | 20% |
| Student > Master | 49 | 15% |
| Researcher | 40 | 12% |
| Student > Bachelor | 30 | 9% |
| Student > Doctoral Student | 14 | 4% |
| Other | 41 | 12% |
| Unknown | 94 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 55 | 16% |
| Chemistry | 35 | 10% |
| Materials Science | 29 | 9% |
| Biochemistry, Genetics and Molecular Biology | 26 | 8% |
| Physics and Astronomy | 20 | 6% |
| Other | 59 | 18% |
| Unknown | 110 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 536. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2021.
All research outputs
#47,275
of 25,870,142 outputs
Outputs from ACS Nano
#19
of 15,678 outputs
Outputs of similar age
#1,017
of 446,951 outputs
Outputs of similar age from ACS Nano
#1
of 237 outputs
Altmetric has tracked 25,870,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,678 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.