| Title |
Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis
|
|---|---|
| Published in |
Environmental Science & Technology, November 2023
|
| DOI | 10.1021/acs.est.3c04347 |
| Pubmed ID | |
| Authors |
Elena Sánchez-Resino, Montse Marquès, Daniel Gutiérrez-Martín, Esteban Restrepo-Montes, María Ángeles Martínez, Albert Salas-Huetos, Nancy Babio, Jordi Salas-Salvadó, Rubén Gil-Solsona, Pablo Gago-Ferrero |
| Abstract |
Understanding the potential impact of organic contaminants on male fertility is crucial, yet limited studies have examined these chemicals in semen, with most focusing on urine and blood. To address this gap, we developed and validated a robust LC-HRMS methodology for semen analysis, with a focus on polar and semipolar chemicals. Our methodology enables the quantitative (or semiquantitative) analysis of >2000 chemicals being compatible with suspect and nontarget strategies and providing unprecedented insights into the occurrence and potential bioaccumulation of diverse contaminants in this matrix. We comprehensively analyzed exogenous organic chemicals and associated metabolites in ten semen samples from Spanish participants collected in an area with a large presence of the chemical industry included in the LED-FERTYL Spanish study cohort. This investigation revealed the presence of various contaminants in semen, including plastic additives, PFAS, flame retardants, surfactants, and insecticides. Notably, prevalent plastic additives such as phthalic acid esters and bisphenols were identified, indicating potential health risks. Additionally, we uncovered previously understudied chemicals like the tire additive 2-mercaptobenzothiazole and specific organophosphate flame retardants. This study showcases the potential of our methodology as a valuable tool for large-scale cohort studies, providing insights into the association between contaminant exposure and the risk of male fertility impairments. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 7 | 19% |
| United Kingdom | 1 | 3% |
| Iran, Islamic Republic of | 1 | 3% |
| Malawi | 1 | 3% |
| Cuba | 1 | 3% |
| India | 1 | 3% |
| Malaysia | 1 | 3% |
| United States | 1 | 3% |
| Germany | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 21 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 47% |
| Scientists | 14 | 39% |
| Science communicators (journalists, bloggers, editors) | 3 | 8% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 2 | 22% |
| Student > Ph. D. Student | 2 | 22% |
| Student > Bachelor | 1 | 11% |
| Lecturer | 1 | 11% |
| Student > Postgraduate | 1 | 11% |
| Other | 0 | 0% |
| Unknown | 2 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 2 | 22% |
| Chemistry | 2 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
| Unspecified | 1 | 11% |
| Medicine and Dentistry | 1 | 11% |
| Other | 1 | 11% |
| Unknown | 1 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 82. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2023.
All research outputs
#531,305
of 25,738,558 outputs
Outputs from Environmental Science & Technology
#780
of 21,032 outputs
Outputs of similar age
#9,245
of 364,889 outputs
Outputs of similar age from Environmental Science & Technology
#18
of 301 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,889 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 301 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.