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DNA Translocations through Nanopores under Nanoscale Preconfinement

Overview of attention for article published in Nano Letters
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
13 news outlets
blogs
3 blogs
facebook
1 Facebook page

Readers on

mendeley
21 Mendeley
Title
DNA Translocations through Nanopores under Nanoscale Preconfinement
Published in
Nano Letters
DOI 10.1021/acs.nanolett.7b03987
Pubmed ID
Authors

Kyle Briggs, Gregory Madejski, Martin Magill, Konstantinos Kastritis, Hendrick W. de Haan, James L. McGrath, Vincent Tabard-Cossa

Abstract

To reduce unwanted variation in the passage speed of DNA through solid-state nanopores, we demonstrate nanoscale pre-confinement of translocating molecules using an ultra-thin nanoporous silicon nitride membrane separated from a single sensing nanopore by a nanoscale cavity. We present comprehensive experimental and simulation results demonstrating that the presence of an integrated nanofilter within nanoscale distances of the sensing pore eliminates the dependence of molecular passage time distributions on pore size, revealing a global minimum in the coefficient of variation of the passage time. These results provide experimental verification that the inter- and intra-molecular passage time variation depends on the conformational entropy of each molecule prior to translocation. Furthermore, we show that the observed consistently narrower passage time distributions enables a more reliable DNA length separation independent of pore size and stability. We also demonstrate that the composite nanofilter/nanopore devices can be configured to suppress the frequency of folded translocations, ensuring single-file passage of captured DNA molecules. By greatly increasing the rate at which usable data can be collected, these unique attributes will offer significant practical advantages to many solid-state nanopore-based sensing schemes, including sequencing, genomic mapping, and barcoded target detection.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 48%
Researcher 3 14%
Unspecified 3 14%
Student > Master 2 10%
Student > Bachelor 1 5%
Other 2 10%
Readers by discipline Count As %
Physics and Astronomy 9 43%
Engineering 8 38%
Unspecified 3 14%
Chemistry 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 111. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2018.
All research outputs
#87,066
of 8,941,737 outputs
Outputs from Nano Letters
#87
of 4,583 outputs
Outputs of similar age
#4,386
of 231,181 outputs
Outputs of similar age from Nano Letters
#4
of 76 outputs
Altmetric has tracked 8,941,737 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,583 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.